Brent J. Small, Ph.D.

Brent J. Small, Ph.D.

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Description of Research Interests

Broadly, my research has examined longitudinal changes, and individual difference predictors of change, in the cognitive functioning of healthy older adults, as well as persons who have been diagnosed with Alzheimer,s disease (AD). In addition, I have pursued a line of research that examines measures of cognitive performance as a means of identifying individuals who are at risk of developing AD. More recently, my work has focused on cognitive changes associated with treatment for cancer, as well as the genetic correlates of this change. Finally, I have been involved on several projects that have applied advanced longitudinal statistical analysis to better understand developmental processes. This includes the use of structural equation modeling, latent change analysis, growth mixture modeling, and random effects models.

Professional Service

Ongoing Research Support (Alphabetical by PI)

F31MH094095 (De Nadai) - 07/01/2013-06/30/2015
NIH/NIMH - $37,481 (annual total costs)
Alliance and Mechanisms of Mediation Adherence in Pediatric Psychiatric Practice
This dissertation support grant will examine adherence to medications among children with anxiety and depression diagnoses.  I will serve as a mentor to Mr. De Nadai as is relates to the best statistical treatment of his study data.
Role:  CollaboratorPercent Effort:  0 Calendar Months (effort in kind)

R01 AG008235 (Dixon) - 09/01/13-08/31/19
NIH/NIA - $373,827 (annual total costs)
Longitudinal Study of Cognitive Aging
In the Victoria Longitudinal Study (VLS), a series of cross-sectional and longitudinal studies pertaining to the description and explanation of changes in cognitive performance in late adulthood are conducted.  The research is designed to examine the extent and trajectories of aging-related cognitive and memory changes, as influenced by (a) patterns of differential decline in theoretically derived classes of influencing/cognitive components, and (b) conditions representing selected physiological, health, and lifestyle characteristics.
Role:  Consultant
Percent Effort:  0 Calendar Months (consultant arrangement)

RSG-12-087-01-CPPB (Jacobsen/Meade) - 1/1/2012 – 12/31/2015
ACS -$1,157,000 (total direct costs)
Self-administered Stress Management Training for Latinas Receiving Chemotherapy
The primary aim of this study is to examine a culturally-tailored stress management intervention among Latinas receiving chemotherapy for cancer.  I am the statistical co-investigator on this project.
Role:  Co-I
Percent Effort:  0.9 Calendar Months (7% of effort)

R21 CA191594 (Jacobsen) - 01/01/15 – 12/31/16
NIH/NCI - $475,141 (total costs)
Internet-Assisted Cognitive Behavior Intervention for Targeted Therapy Fatigue
The proposed research focuses on the development and initial evaluation of a cognitive behavior intervention (delivered via videotelephony) that is designed to address fatigue in patients with chronic myelogenous leukemia being treated with extended oral therapy.
Role:  Co-I
Percent Effort:  0.36 Calendar Months (3% of effort)

R01 CA164109 (Jim) - 09/01/12 – 08/31/17
National Cancer Institute - $545,516 (annual total costs)
Sickness Behaviors During Chemotherapy for Cancer
The major goals of the project are to examine immunologic predictors of longitudinal changes in sleep, fatigue, and depression in gynecologic cancer patients undergoing chemotherapy.
Role:  Co-I
Percent Effort:  1.2 Calendar Months (10% of effort)

(McMillan) - 05/01/2013-04/30/2016
PCORI - $1,984,020 (total direct costs)
Patient Outcomes of a Self-care Management Approach to Cancer Symptoms: A Clinical Trial
The goal of this project is to evaluate the COPE intervention as it relates to cancer symptom management among persons undergoing active treatment.
Role:  Co-I
Percent Effort:  1.8 Calendar Months (15% of effort)

(Rivers) - 05/01/2013-04/30/2016
PCORI - $1,336,457 (total direct costs)
Navigator Guided e-Psychoeducational Intervention for Prostate cancer Patients and their Caregivers
The objectives of this community-based randomized control trial are to examine the impact on QOL outcomes of a six-week community navigator (CN) guided psychoeducational intervention (PHIN) versus print education (PE) among men who are newly diagnosed with prostate cancer and their caregivers.
Role:  Co-I
Percent Effort:  1.2 Calendar Months (10% of effort)

(Scott) - 12/31/14-12/30/15
American Cancer Society – Institutional Research Grant
Daily Cognitive Functioning Among Cancer Survivors
The objective of this project is to examine daily cognitive functioning among breast cancer survivors using smartphones.  The aims of the study are: (1) To examine the correspondence between objective assessments of cognitive performance and subjective memory failures in daily life; and (2) To identify characteristics of individuals and features of their daily experiences that predict which survivors will show cognitive deficits and when they will report cognitive difficulties.
Role:  Co-I
Percent Effort:  0.0 Calendar Months (0% of effort; no salary support allowed)

2P30CA76292-08 (Sellers) - 02/01/2012 – 01/31/2017
NIH/NCI - $2,787,198 (total direct costs)
H. Lee Moffitt Cancer Center and Research Institute Support Grant
To provide leadership for the cancer center which includes cell biology, immunology, clinical investigations and cancer control.
Role: Co-I (Biostatistician)
Percent Effort:  0.12 Calendar Months (1% of effort)

R01 MH093381 (Storch) - 07/01/2011-02/28/2015
NIH/NIMH - $225,000 (annual direct costs)
1/2-D-Cycloserine Augmentation of CBT for Pediatric OCD
The goal of this project is to examine whether augmenting cognitive behavioral therapy with 1/2-D-Cycloserine for children with Obesessive-Compulsive Disorder will improve response to treatment.  This study represents an innovative approach in translating bench research findings into clinical research and testing a new approach for augmenting an effective psychotherapy with a safe non-psychotropic medication. I serve as statistical co-investigator on this grant.
Role:  Co-I
Percent Effort:  0.6 Calendar Months (5% of effort)

R01 MH100212 (Storch) - 01/01/2013-12/31/2016
NIH/NIMH - $150,000 (annual direct costs)
2/3 Treatment of Anxiety in Autism Spectrum Disorder
The current project proposes a randomized clinical trial to eventual the efficacy of cognitive-behavioral therapy relative to an education/support/attention active control condition to alleviate anxiety symptoms among children with Autism spectrum disorders.
Role:  Co-I
Percent Effort:  0.36 Calendar Months (3% of effort)

Selected Peer-Reviewed Journal Publications:  Published and in press  (* indicates student first author)

  1. *Handing, E. P., Small, B. J., Reynolds, S. L. & Kumar, N. B. (in press).  Impact of dietary factors and inflammation on cognition among older adults.  The Journal of Prevention of Alzheimer’s Disease.
  2. *Haghighi M, Smith A, Morgan D, Small BJ, Huang S. Identifying Cost-Effective Predictive Rules of Amyloid-beta Level by Integrating Neuropsychological Tests and Plasma-Based Markers. Journal of Alzheimer's disease : JAD. 2014. Epub 2014/08/26. doi: 10.3233/JAD-140705. PubMed PMID: 25147105.
  3. *Hahn, E. A., Cichy, K. E., Small, B. J., & Almeida, D. M. (2014). Daily Emotional and Physical Reactivity to Stressors Among Widowed and Married Older Adults. The Journals of Gerontology Series B: Psychological Sciences and Social Sciences, 69 (1), 19-28. doi: 10.1093/geronb/gbt035. PMID: 23685921.
  4. Jim HS, Barata A, Small BJ, Jacobsen PB, Pidala J. Quality of life associated with sirolimus for prevention of graft-versus-host disease: results from a randomized trial. Haematologica. 2014;99(3):548-53. Epub 2013/11/19. doi: 10.3324/haematol.2013.088781. PubMed PMID: 24241491; PubMed Central PMCID: PMC3943320.
  5. *McGinty HL, Phillips KM, Jim HS, Cessna JM, Asvat Y, Cases MG, Small BJ, Jacobsen PB. Cognitive functioning in men receiving androgen deprivation therapy for prostate cancer: a systematic review and meta-analysis. Support Care Cancer. 2014;22(8):2271-80. Epub 2014/05/27. doi: 10.1007/s00520-014-2285-1. PubMed PMID: 24859915; PubMed Central PMCID: PMC4090762.
  6. *Runge SK, Small BJ, McFall GP, Dixon RA. APOE moderates the association between lifestyle activities and cognitive performance: evidence of genetic plasticity in aging. J Int Neuropsychol Soc. 2014;20(5):478-86. Epub 2014/05/29. doi: 10.1017/S1355617714000356. PubMed PMID: 24867440.
  7. Small, B. J., Rawson, K. S., Martin, C., Eisel, S. L., Sanberg, C. D., McEvoy, C. L., . . . Bickford, P. C. (2014). Nutraceutical intervention improves older adults' cognitive functioning. Rejuvenation Res, 17(1), 27-32. doi: 10.1089/rej.2013.1477
  8. Storch, E. A., Wu, M. S., Small, B. J., Crawford, E. A., Lewin, A. B., Horng, B., & Murphy, T. K. (2013). Mediators and moderators of functional impairment in adults with obsessive-compulsive disorder. Compr Psychiatry. doi: 10.1016/j.comppsych.2013.10.014
  9. *Allen, J. Y., Haley, W. E., Small, B. J., Schonwetter, R. S., & McMillan, S. C. (2013). Bereavement among Hospice Caregivers of Cancer Patients One Year following Loss: Predictors of Grief, Complicated Grief, and Symptoms of Depression. J Palliat Med, 16(7), 745-751. doi: 10.1089/jpm.2012.0450. PMID: 23697816.
  10. *Ata, R. N., Thompson, J. K., & Small, B. J. (2013). Effects of exposure to thin-ideal media images on body dissatisfaction: Testing the inclusion of a disclaimer versus warning label. Body Image 10 (4), 472-480. doi: 10.1016/j.bodyim.2013.04.004. PMID: 23688859.
  11. *Castora-Binkley M, Peronto CL, Edwards JD, Small BJ. A Longitudinal Analysis of the Influence of Race on Cognitive Performance. J Gerontol B Psychol Sci Soc Sci. 2013. Epub 2013/11/05. doi: 10.1093/geronb/gbt112. PubMed PMID: 24184780.
  12. Donovan, K. A., Gonzalez, B. D., Small, B. J., Andrykowski, M. A. & Jacobsen, P. B. (2013).  Depressive symptom trajectories during and after adjuvant treatment for breast cancer.  Annals of Behavioral Medicine. doi: 10.1007/s12160-013-9550-2
  13. Jacobsen, P. B., Phillips, K. M., Jim, H. S. L., Small, B. J., Faul, L. A., Meade, C. D., Thompson, L., Williams Jr., C. C., Loftus, L. S., Fishman, M. & Wilson, R. W. (2013).  Effects of self-directed stress management training and home-based exercise on quality of life in cancer patients receiving chemotherapy:  A randomized controlled trial.  Psycho-Oncology, 22 (6), 1229-1235. PMID: 22715124.
  14. Jim, H. S., Jacobsen, P. B., Phillips, K. M., Wenham, R. M., Roberts, W., & Small, B. J. (2013). Lagged relationships among sleep disturbance, fatigue, and depressed mood during chemotherapy. Health Psychol, 32(7), 768-774. doi: 10.1037/a0031322. PMID: 23437852. PMCID:PMC3700563
  15. Phillips, K. M., Faul, L. A., Small, B. J., Jacobsen, P. B., Apte, S., & Jim, H. S. L. (2013). Comparing the Retrospective Reports of Fatigue using the Fatigue Severity Index to Daily Diary Ratings in Women Receiving Chemotherapy for Gynecologic Cancer.  Journal of Pain and Symptom Management, 46 (2), 282-288. PMID: 23159686.
  16. Phillips, K. M., McGinty, H. L. Cessna, J., Asvat, Y., Gonzalez, B., Cases, M., Small, B. J., Jacobsen, P. B., Pidala, J. & Jim, H. S. L. (2013).  A systematic review and meta-analysis of changes in cognitive functioning in adults undergoing hematopoietic cell transplantation.  Bone Marrow Transplantation, 48 (10), 1350-1357. PMID: 23645166.
  17. Phillips, K. M., McGinty, H. L., Gonzalez, B. D., Jim, H. S., Small, B. J., Minton, S., Andrykowski, M. A. & Jacobsen, P. B. (2013).  Factors associated with breast cancer worry 3 years after completion of adjuvant treatment.  Psychooncology, 22 (4) 936-939, PMID: 22419546.
  18. Phillips, K. M., Pinilla-Ibarz, J., Sotomayor, E., Lee, M. R., Jim, H. S. L., Small, B. J., Sokol, L., Lancet, J., Tinsley, S., Sweet, K., Komrokji, R. & Jacobsen, P. B. (2013). Quality of life outcomes in patients with Chronic Myeloid Leukemia treated with Tyrosine Kinase Inhibitors: A controlled comparison.  Supportive Care in Cancer, 21 (4), 1097-1103. PMID: 23179489
  19. Simmons, V. N., Heckman, B. W., Fink, A. C., Small, B. J., & Brandon, T. H. (2013). Efficacy of an experiential, dissonance-based smoking intervention for college students delivered via the Internet. J Consult Clin Psychol, 81(5), 810-820. doi: 10.1037/a0032952.
  20. Storch, E. A.,Bussing, R., Small, B. J., Geffken, G. R., McNamara, J. P., Rahman, O., Lewin, A. B., Garvan, C. S., Goodman, W. K., & Murphy, T. K. (2013).  Randomized, Placebo-Controlled Trial of Cognitive-Behavioral Therapy Alone or Combined with Sertraline in the Treatment of Pediatric Obsessive-Compulsive Disorder. Behaviour Research and Therapy, 51(12), 823-829. doi: 10.1016/j.brat.2013.09.007.
  21. Cao, C., Loewenstein, D. A., Lin, X., Zhang, C., Wang, L., Duara, R., Wu, Y., Bai, G., Grieg, M., Schofield, E., Raj, A., Small, B. J., Potter, H. & Arendash, G. W. (2012).  High blood caffeine levels in MCI linked to lack of progression to dementia.  Journal of Alzheimer’s Disease, 30 (3), 559-572. Doi: 10.3233/JAD-2012-111781.  PMID: 22430531
  22. Goedendorp, M. M., Andrykowski, M. A., Donovan, K. A., Jim, H. S., Phillips, K. M., Small, B. J., Laronga, C. & Jacobsen, P. B. (2012).  Prolonged impact of chemotherapy on fatigue in breast cancer survivors: A longitudinal comparison with radiotherapy treated breast cancer survivors and non-cancer controls.  Cancer, 118 (15), 3833-3841. doi: 10.1002/cncr.26226. PMID:  22086766. PMCID:PMC4007757
  23. Jim, H. S. L., Park, J. Y., Permuth-Way, J., Rincon, M. A., Phillips, K. M., Small, B. J. & Jacobsen, P. B. (2012).  Genetic predictors of fatigue in prostate cancer patients treated with andogren deprivation therapy.  Brain, Behavior & Immunity, 26 (7), 1030-1036. PMID: 22475653. Doi: 10.1016/j.bbi.2012.03.001
  24. Jim, H. S., Phillips, K. M., Chait, S., Faul, L. A., Popa, M. A., Lee, Y. H., . . . Small, B. J. (2012). Meta-analysis of cognitive functioning in breast cancer survivors previously treated with standard-dose chemotherapy. J Clin Oncol, 30(29), 3578-3587. doi: 10.1200/JCO.2011.39.5640. PMID: 22927526
  25. Jim, H. S. L., Small, B. J., Minton, S., Andrykowski, M. A., & Jacobsen, P. B. (2012). History of Major Depressive Disorder Prospectively Predicts Worse Quality of Life in Women with Breast Cancer. Annals of Behavioral Medicine, 43 (3), 402-408. doi: 10.1007/s12160-011-9333-6. PMID: 22167580.
  26. *O’Connor, M. L., Edwards, J. D., Small. B. J. & Andel, R. (2012).  Self-regulation of driving behaviors over time in older adults.  Journal of Gerontology:  Psychological Sciences, 67 (4), 437-446. Doi: 10.1093/geronb/gbr122
  27. Phillips, K. M., Jim, H. S. L., Small, B. J., Tanvetyanon, T., Williams, R. & Jacobsen, P. B. (2012).  Effects of self-directed stress management training and home-based exercise on stress management skills in cancer patients receiving chemotherapy.  Stress & Health, 28 (5), 368-375. Doi:  10.1002/smi.2450.  PMID: 22972771
  28. Phillips, K. M., Jim, H. S., Small, B. J., Laronga, C., Andrykowski, M. A., & Jacobsen, P. B. (2012). Cognitive functioning after cancer treatment: A 3-year longitudinal comparison of breast cancer survivors treated with chemotherapy or radiation and noncancer controls. Cancer, 118 (7), 1925-1932. doi: 10.1002/cncr.26432. PMID: 22161750
  29. Prakash, R., Rastogi, P., Dubey, I., Abhishek, P., Chaudhury, S., & Small, B. J. (2012). Long-term concentrative meditation and cognitive performance among older adults. Aging, Neuropsychology, and Cognition, 19 (4), 479-194. doi: 10.1080/13825585.2011.630932. PMID:  22149237.
  30. Small, B. J.,Dixon, R. A., McArdle, J. J., & Grimm, K. J. (2012).  Changes in lifestyle activities as moderators of age-related declines in cognitive abilities:  Evidence from the Victoria Longitudinal Study.  Neuropsychology, 26 (2), 144-155. PMCID: PMC3761970. Doi: 10.1037/a0026579

Honors and Awards

2011

Fellow, Association for Psychological Science

2007

Sue V. Saxon Outstanding Teaching Award, School of Aging Studies, University of South Florida, Tampa, Florida.

2005

Outstanding Faculty Research Achievement Award, University of South Florida, Tampa, Florida.

2004

The Margret M. Baltes Early Investigator Award in Behavioral and Social Gerontology, Gerontological Society of America.

2004

Fellow, Division 20 (Adult Development and Aging), American Psychological Association

2003

Fellow, Behavioral and Social Sciences Section, Gerontological Society of America

2002 President’s Award for Faculty Excellence, University of South Florida, Tampa, Florida
2001

Outstanding Undergraduate Teaching Award, University of South Florida, Tampa, Florida

Classes Taught

GEY 4401 - Research Methods in Gerontology
GEY 6403 - Advanced Statistics and Research Methods
GEY 6934 - PhD Seminar in Cognitive Aging
GEY 6934 - PhD Seminar in Psychological Aging